منابع مشابه
SUMO wrestling with Ras
This review discusses our current understanding of the small ubiquitin-like modifier (SUMO) pathway and how it functionally intersects with Ras signaling in cancer. The Ras family of small GTPases are frequently mutated in cancer. The role of the SUMO pathway in cancer and in Ras signaling is currently not well understood. Recent studies have shown that the SUMO pathway can both regulate Ras/MA...
متن کاملWrestling with rep exposure
A central methodological problem in programming with multiple levels of abstractions is the loosely defined problem of rep exposure. This paper traces the problem of rep exposure to the precisely defined notion of abstract aliasing. The paper also outlines a statically-enforceable discipline for avoiding abstract aliasing, but the outline is incomplete.
متن کاملDeciding the Undecidable: Wrestling with Hilbert’s Problems
In the year 1900, the German mathematician David Hilbert gave a dramatic address in Paris, at the meeting of the 2nd International Congress of Mathematicians—an address which was to have lasting fame and importance. Hilbert was at that point a rapidly rising star, if not superstar, in mathematics, and before long he was to be ranked with Henri Poincaré as one of the two greatest and most influe...
متن کاملWrestling the Giant
In the recent past, the clinical availability of genetic information has increased exponentially and with it the opportunity to use this information to aid in diagnosis and treatment of cardiovascular disease. One of the greatest challenges we face with this wealth of potentially useful diagnostic information is determining the pathogenicity of the myriad genetic variants identified. Dilated ca...
متن کاملSUMO Modification: Wrestling with Protein Conformation
SUMO modification of human thymine-DNA glycosylase facilitates the processing of base excision repair substrates by an unusual mechanism: while leaving the catalytic center unaffected, it induces product release by eliciting a conformational change in the enzyme.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Lancet Psychiatry
سال: 2015
ISSN: 2215-0366
DOI: 10.1016/s2215-0366(15)00040-1